Pregabalin + Nortriptyline is a combination of two medicines: Pregabalin and Nortriptyline. Pregabalin is an alpha 2 delta ligand which decreases the pain by modulating calcium channel activity of the nerve cells. Nortriptyline is a tricyclic antidepressant which increases the levels of chemical messengers that stop the movement of pain signals in the brain. Together, they relieve neuropathic pain.